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KMID : 0359720140320030168
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Journal of the Korean Neurological Association
2014 Volume.32 No. 3 p.168 ~ p.170
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Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate
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Lee Ju-Youn
Oh Eung-Seok
Jeong Seong-Hae
Sohn Eun-Hee
Lee Ae-Young
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Abstract
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Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX.
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KEYWORD
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Leukoencephalopathy, Methotrexate, Cerebellum
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